Biofiller PRF (Platelet-Rich Fibrin)

What Is Biofiller (Natural Filler)?

Biofiller is a platelet-rich fibrin (PRF) structure prepared entirely from the person’s own blood, concentrated with special techniques and brought into an injectable form. This structure contains the body’s own healing cells and growth factors.

Unlike classic PRP, Biofiller PRF contains no additives or chemical gel — it is a completely biological and natural filler. This is why it is called a “natural filler”.

After the procedure, the fibrin network that settles in the area continues the cellular repair process for weeks thanks to slowly released growth factors.

How Does Biofiller Work in Joint Osteoarthritis?

Joint osteoarthritis occurs with the thinning of the cartilage on the joint surface. Over time, the joint fluid decreases, the bones begin to rub against each other and pain during movement appears. Biofiller (PRF) offers a regenerative treatment that can reverse this process.

• The growth factors in PRF stimulate cartilage cells,
• Collagen production increases,
• The space between the joints (joint space) widens,
• The quality of the joint fluid improves,
• Pain and restricted movement decrease.

In short, Biofiller targets not just the symptom but the cause of the problem. It restructures the joint, supports cartilage regeneration and allows the patient to move without pain.

When Is It Used?

The Biofiller (Natural Filler) method is applied successfully, especially in the following conditions:

• Knee osteoarthritis (gonarthrosis)
• Hip osteoarthritis (coxarthrosis)
• Meniscus tears
• Sports injuries and muscle-tendon strains
• Pain related to cervical and lumbar disc herniation
• Wear and tear of the spine and the areas around joints

This treatment both reduces pain and increases mobility, thereby giving patients their quality of life back.

How Is Biofiller (PRF) Treatment Performed?

• Preparation: A small amount of blood is drawn from the patient.
• Centrifuge process: The blood is spun at low speed in a special device, and a layer rich in fibrin and platelets is obtained.
• Creating the biofiller: The PRF obtained is brought into “biofiller” form with a special heat protocol; a natural filler with a gel consistency is obtained.
• Application: The prepared biofiller is injected under sterile conditions into the joint, the tendon tissue or the area around the muscle.

The whole procedure is natural, painless and takes about 20–30 minutes. It is performed with local anesthesia, and no hospital stay is required.

Session Plan and Process

Biofiller treatment is applied at 1–2 month intervals, depending on the patient’s condition. A protocol of 2–3 sessions is generally recommended.

• Pain decreases in the joints,
• Walking and mobility increase,
• The joints become stronger and more flexible.

As treatment progresses, this healing effect accumulates; as a result, joint durability increases and the progression of the disease slows down.

Benefits of Biofiller Treatment

• It is a completely natural method; it is obtained from the person’s own blood and contains no chemicals.
• It supports cartilage regeneration: It nourishes the joint surfaces and improves tissue quality.
• It reduces pain and increases movement; it makes daily activities easier.
• It is an alternative to surgery or a supportive option; in early and mid-stage osteoarthritis it offers a non-surgical solution.
• It provides a long-lasting effect; because the fibrin network releases growth factors slowly, its effect continues for weeks.

What Is the Difference Between Biofiller PRF and PRP?

• PRP is in liquid form, and its duration of effect may be short (3–5 days).
• PRF (Biofiller) has a gelled structure and maintains its effect for up to 10 days.
• PRF contains clotting factors and a fibrin network; as a result, growth factors are released over a long time.
• PRF contains no anticoagulant or additives — it is a completely biological method.

In short: PRP renews, while PRF renews and protects for a long time.

What to Pay Attention to After the Procedure

• Mild tenderness or tightness may be felt after the procedure; this is normal.
• 24 hours of rest is recommended; no heavy exercise for the first 2–3 days.
• Drinking plenty of water supports circulation.
• Painkillers are not used in the first days, because the natural inflammation process is part of healing.
• Exercises should be added to the treatment in line with the physiotherapist’s recommendations.

Frequently Asked Questions (FAQ)

1. Is Biofiller (PRF) a painful procedure? No. Local anesthesia is applied during the procedure; patients feel only a slight fullness.
2. Is Biofiller treatment permanent? Yes; it enables the tissues to repair themselves. Its effect accumulates over time and the tissue structure becomes stronger.
3. Can it be applied to every age group? It can generally be applied safely to patients between 25 and 75 years of age.
4. Can it be used in patients who have had surgery? Yes; it can be applied as a supportive treatment, especially before or after knee or hip replacement.
5. Is PRF applied only to joints? No; it is also used in muscle-tendon injuries, meniscus tears, sports injuries and even facial rejuvenation procedures.

Conclusion: Let Your Joints Be Renewed with Your Own Blood

Biofiller (PRF – Platelet Rich Fibrin) is a natural filler and repair method produced from the body’s own blood. It contains no chemical or foreign substances; it activates the body’s biological power of renewal.

• Reduces pain
• Strengthens the joints
• Renews the cartilage structure
• Gives back natural mobility

In our clinic, this method is applied successfully especially in knee and hip osteoarthritis, as well as in sports injuries and meniscus injuries. As the sessions progress, the joints become stronger, pain decreases and quality of life improves.